Cancer Of The Pancreas : Causes & Risk Factors

Definition
Pancreatic carcinoma is cancer of the pancreas. Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming the pancreas.

The most common type of pancreatic cancer, accounting for 95% of these tumors, is adenocarcinoma (tumors exhibiting glandular architecture on light microscopy) arising within the exocrine component of the pancreas. A minority arise from islet cells, and are classified as neuroendocrine tumors.

Causes
The pancreas is a large organ that is found behind the stomach. It makes and releases enzymes that help the body absorb foods, especially fats. Hormones called insulin and glucagon are also made in the pancreas. These hormones help your body control blood sugar levels.The exact cause is unknown, but pancreatic cancer is more common in smokers and people who are obese.

Risk Factors

  • Family history: 5–10% of pancreatic cancer patients have a family history of pancreatic cancer. The genes have not been identified.
  • The risk of developing pancreatic cancer increases with age. Most cases occur after age 60, while cases before age 40 are uncommon.
  • Cigarette smoking has a risk ratio of 1.74 with regard to pancreatic cancer; a decade of nonsmoking after heavy smoking is associated with a risk ratio of 1.2.
  • Diets low in vegetables and fruits
  • Diets high in red meat.
  • Diets high in sugar-sweetened drinks
  • Obesity
  • Diabetes mellitus
  • Helicobacter pylori infection
  • Gingivitis or periodontal disease

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